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Synlett 1991; 1991(1): 35-36
DOI: 10.1055/s-1991-20619
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1-(α-Diazobenzyl)pyrene: A Reagent for Photolabile and Fluorescent Protection of Carboxyl Groups of Amino Acids and Peptides

Michiko Iwamura* , Chikako Hodota, Masami Ishibashi
  • *Department of Biomolecular Science, Faculty of Science, Toho University, Miyama, Funabashi, Chiba 274, Japan
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Publication Date:
07 March 2002 (online)

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1-(α-Diazobenzyl)pyrene (1c), red prisms stable at room temperature for more than three months, reacted with the p-toluenesulfonic acid salts of amino acids to give the corresponding highly fluorescent amino acid α-(1-pyrenyl)benzyl ester salts in moderate yield. The amino acids were recovered by irradiation at 340 nm in methanol. Application of this method to dipeptides is also described.